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Two Cases of Myasthenia Gravis Showing Fatigibility Presenting with Decreased Gain of Smooth Pursuit
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Ju-Hee Chae, Hyun-June Shin, Byoung-Soo Shin, Man-Wook Seo, Sun-Young Oh
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Res Vestib Sci. 2019;18(2):54-58. Published online June 15, 2019
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DOI: https://doi.org/10.21790/rvs.2019.18.2.54
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 Abstract
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- Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies to the acetylcholine receptors of the neuromuscular junction characterized by weakness and abnormal fatigability of the muscles. Therefore, the diagnosis of MG depends on the recognition of this distinctive pattern of fatigable weakness. Previous studies presented the diagnostic efficacy of saccadic eye movements in patients with ocular MG. We here in report 2 patients of ocular MG showing the fatigue effects during repetitive sustained smooth pursuit, and the effects of the administration of edrophonium on myasthenic smooth pursuit. Changes in smooth pursuits reflecting peripheral and secondary central mechanisms were demonstrated.
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Citations
Citations to this article as recorded by  - Tracking Eye Movements for Diagnosis in Myasthenia Gravis: A Comprehensive Review
Minh N. L. Nguyen, Anneke van der Walt, Joanne Fielding, Meaghan Clough, Owen B. White
Journal of Neuro-Ophthalmology.2022; 42(4): 428. CrossRef
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원활추종운동 이득감소로 근피로도를 확인한 중증근무력증 2예
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Ju-Hee Chae, Hyun-June Shin, Byoung-Soo Shin, Man-Wook Seo, Sun-Young Oh
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Received April 9, 2019 Accepted June 3, 2019 Published online June 3, 2019
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[Accepted]
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Abstract
- Myasthenia Gravis (MG) is an autoimmune disease caused by autoantibodies to the acetylcholine receptors of the neuromuscular junction characterized by weakness and abnormal fatigability of the muscles. Therefore, the diagnosis of MG depends on the recognition of this distinctive pattern of fatigable weakness. Previous studies presented the diagnostic efficacy of saccadic eye movements in patients with ocular MG. We here in report two patients of ocular MG showing the fatigue effects during repetitive sustained smooth pursuit, and the effects of the administration of edrophonium on myasthenic smooth pursuit. Changes in smooth pursuits reflecting peripheral and secondary central mechanisms were demonstrated.
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